Agree with the above - doubt ANY skyline short of a full on race prepped one will ever match an Enzo for handling.
But then can the Enzo do the sub-one minute lap of Tsukuba, and then take the wife and two kids home with th eovernight luggage...
Different cars for different purposes. I'm not sure how far an NSX Type-R can be tuned power wise, but I would have thought that it would be the closest Jap car to an Enzo in terms of handling? A 600bhp NSX-R??
Having said that I recall seeing a certain Mr Clarkson take apart a Murcielago with an Evo FQ 400 so perhaps a nicely set up Skyline would have a chance...
As with all these hypothetical questions - its all down to a drivers ability in his car, and his willingness to risk it all to get a better time.
Ash